Children's Hospital Colorado

Research at the Breathing Institute

The Breathing Institute at Children's Hospital Colorado is one of the world's premier programs for treating children with breathing disorders. We are internationally known for our team's clinical and research leadership roles in caring for children with conditions including asthma, bronchopulmonary dysplasia (BPD), cystic fibrosis (CF), pulmonary hypertension (PH), sleep disorders, primary ciliary dyskinesia (PCD), interstitial and diffuse lung disease, and for associated basic science research.

We offer a top pediatric pulmonology fellowship program with the University of Colorado School of Medicine. We're located near the University of Colorado Hospital and the University of Colorado School of Medicine on the Anschutz Medical Campus. This partnership enables us to work with some of the best minds in academic research.

Research article

There's currently no technology to measure the structure and function of the lungs, particularly in kids. At Children's Colorado, electrical impedance tomography (EIT) will change that.

Clinical trial

The Preventing Asthma in High Risk Kids (PARK) study hopes to study asthma prevention with Xolair™, a medication approved for children 6 years or older. Learn more about the PARK asthma study here.

Diagnosis
Children who have had two to four wheezing episodes in the past year and have a family member with allergies or asthma.
Age
24-47 months

Our pulmonary advancements

We're focused on transforming care and finding cures through innovation. Some of our team's advancements include:

  • Our physicians have led the way in Cystic Fibrosis (CF) research. Frank Accurso, MD, was the head of the national clinical trial that led to FDA approval of Kalydeco, the first drug that treats the underlying causes of CF.
  • We're using novel preliminary protein markers for rare lung disease diagnosis and for CF correlation of structural lung injury and lung function decline
  • The innovative approach in our Ventilator Care Program has resulted in improved communication and continuity of care, and has led to a significant increase in survival rates for these fragile infants.
  • Our team developed an authentic 3-D bronchoscopy training tool to improve procedural competency. In one test of the model on trainees with zero scope experience, 92% could identify all lobes of the bronchi successfully after less than two hours of training.

In 2017, the Breathing Institute had 65 active awards combined, which included awards from the National Institutes of Health (NIH), foundation and industry awards. These awards provided more than 15 million dollars of funding for our pulmonary research.

"Our team works tirelessly to get our patients home safely with their families. Innovation and research help us better care for technology-dependent children at home."

Christopher Baker, MD

Director, Ventilator Care Program

Learn about Dr. Baker's research

What our pulmonary research means for kids

Our mission in the Breathing Institute is to be a national leader in improving patient outcomes, finding new treatments and developing cures for children with breathing and sleep disorders. Our focus centers on five key components:

  • Pursuing basic scientific studies that are crucial to understanding breathing and pulmonary vascular disorders in children.
  • Finding new opportunities for personalized medicine in translational and clinical research.
  • Developing novel strategies and interdisciplinary teams for the management, prevention and cure of childhood lung diseases.
  • Careful tracking of clinical outcomes for treatment effectiveness and patient safety.
  • Training the next generation of clinicians and clinician-scientists for advancing the care of children with lung disease.
  • Promoting healthier communities through our school and home-based asthma education and medication adherence programs, including the Just Keep Breathing program and the Step Up Asthma program.
  • We've developed a new outpatient nasal esophagoscopy with esophageal biopsy to replace higher-risk procedures for patients.

Creating a clinical practice guideline for home oxygen therapy for children

Although home oxygen therapy is commonly required to care for children with respiratory conditions, there is a striking lack of empirical evidence regarding implementation, monitoring and discontinuation of supplemental oxygen therapy. In some cases, insurance companies and durable medical equipment suppliers apply adult standards for oxygen use that are unsafe for kids. Children and infants have specialized needs for their growing brains and bodies, and their respiratory care should be treated differently than adults.

Robin Deterding, MD, senior author and co-chair of the subcommittee that authored this research, and Don Hayes Jr., MD at Nationwide Children’s and co-chair of the committee, worked together to identify the challenges with home oxygen therapy specific to both pediatric lung disease and pulmonary vascular disease. Joyce Baker, clinical coordinator for Respiratory Therapy, Steven H. Abman, MD, and Stephen Hawkins, MD, from the Breathing Institute at Children’s Colorado participated as members of a multidisciplinary panel and conducted systematic reviews of relevant literature to set a new standard of care for oxygen use in children. Based on this review, the panel developed an official clinical practice guideline featuring recommendations for or against the use of home oxygen therapy based on each condition.

Read the article “Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline.”

Early pulmonary vascular disease in preterm infants Is associated with late respiratory outcomes in childhood

Despite marked advances in perinatal care, preterm infants remain at high risk for chronic lung disease, known as bronchopulmonary dysplasia (BPD). BPD is often associated with poor outcomes, such as prolonged ventilator support, lengthy NICU stays, persistent respiratory failure and late respiratory disease during early childhood. Past experimental work from the Pediatric Heart Lung Center (PHLC) showed that the development of pulmonary vascular disease (PVD) during the perinatal period causes high risk for BPD and for pulmonary hypertension (PH) in rodents. This prospective study, featuring several providers from Children’s Colorado, confirmed this concept in human infants. Researchers determined that early signs of PVD in preterm neonates on day 7 of life increased the susceptibility for BPD as well as late breathing problems, such as frequent ER visits, rehospitalizations and the need for respiratory medications throughout the first 2 years of life. These data further suggest that identifying PVD in preterm infants at day 7 may allow future interventions to prevent late lung disease after preterm birth.

Read the article “Early Pulmonary Vascular Disease in Preterm Infants Is Associated with Late Respiratory Outcomes in Childhood.”

Using aptamer-based proteomics to analyze cystic fibrosis bronchoalveolar lavage fluid

Biomarkers are essential in treating cystic fibrosis because they allow providers to understand disease progression, evaluate therapy’s effectiveness and improve enrollment for clinical trials. Aptamer-based proteomics, the study of particular oligonucleotide or peptide molecules, has been useful in identifying biomarkers in blood samples. This study aimed to apply this same method of study to bronchoalveolar lavage fluid (BALF), which is fluid gently sprayed into the lungs via a bronchoscope and then collected for analysis.

The study compared BALF in children with cystic fibrosis to disease control groups to identify endotypes (clinical subtypes of cystic fibrosis) during cystic fibrosis exacerbations. The researchers identified increased concentrations of proteins associated with inflammation and decreased concentrations of protein folding and host defense proteins in the cystic fibrosis group compared to disease controls. Based on this, they also identified two distinct endotypes within the cystic fibrosis group of the study. This research suggests that aptamer-based proteomics can differentiate between groups and determine endotypes within cystic fibrosis.

Read the full article, “Novel Application of Aptamer Proteomic Analysis in Cystic Fibrosis Bronchoalveolar Lavage Fluid.”

Oxygen saturations and neurodevelopmental outcomes in single ventricle heart disease

In this study, researchers evaluated whether the degree of hypoxemia following stage-I and stage-II palliative surgeries predicts neurodevelopmental outcomes at 14 months of age in children with single ventricle congenital heart disease (SVCHD). Researchers measured oxygen saturation via pulse oximetry at discharge from stage-I and stage-II palliative surgeries and developmental scores at 14 months old. This study showed that oxygen saturation levels following these surgeries did not relate to neurodevelopment scores. Neither oxygen saturation measurements below 80% nor changes in oxygen saturation levels were associated with neurodevelopment scores. Researchers concluded that the relationship between oxygen saturation levels and neurodevelopment in patients with SVCHD is complex. Pulse oximetry readings following these palliative surgeries is not a reliable predictor of future neurodevelopmental risk and may be an insufficient proxy for cerebral oxygen delivery.

Read the full article “Oxygen saturations and neurodevelopmental outcomes in single ventricle heart disease.”

Inpatient provider survey on steroid preferences for children with asthma

The Children’s Colorado pediatric emergency department began using dexamethasone for treating asthma exacerbations after studies showed it was as effective as prednisone. However, providers have not reached consensus on using prednisone or dexamethasone for inpatients. This study evaluated provider preference for inpatient steroid treatment. Researchers found that inpatient provider preference varied, with most providers reporting that it depends on the scenario. Researchers concluded that use of dexamethasone in the emergency department has led to uncertainty in inpatient steroid prescribing practices. Providers often revert to prednisone, especially in severe asthma exacerbations, possibly due to experience with prednisone and limited research on dexamethasone in the inpatient setting.

Read the article “Steroid variability in pediatric inpatient asthmatics: survey on provider preferences of dexamethasone versus prednisone.”

Learn more about the Breathing Institute.

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